자로스코바 리브스,린더스 요아네스 테오도루스 마리아,반 데르 베켄 루이스 조제프 엘리자벳,윌렘스네스 구스타프 헨리 마리아
申请号：
KR1020077007047
公开号：
KR1011976720000B1
申请日:
2005.08.26
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents C or N； Y represents C or N； L represents a methyl or a direct bond； Z1 represents a direct bond, C1-2alkyl- or a divalent radical of formula -CH2-CH= (a) or -CH= (b)； Z2 represents a direct bond, C1-2alkyl- or a divalent radical of formula -CH2-CH= (a) or -CH= (b)； R1 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR3R4 or C1-4alkyl optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR5R6 or R1 represents C1-4alkyloxy- optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR7R8； R2 represents hydrogen, halo, C1-4alkyl or C1-4alkyloxy-； R3 and R4 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R5 and R6 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R7 and R8 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； A represents phenyl or a monocyclic heterocycle selected from the group consisting of thiophenyl, furanyl, oxazolyl, thiazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyrridinyl, pyridazinyl, pyrimidinyl and piperazinyl.화학식(I) 및 (I bis)의 화합물은 비만 치료용 11 베타-HSD1 저해제로서 유용하다.
