Libuse Jaroskova;Louis Jozef Elisabeth Van Der Veken;Gustaaf Henri Maria Willemsens;Joannes Theodorus Maria Linders
发明人:
Libuse Jaroskova,Joannes Theodorus Maria Linders,Louis Jozef Elisabeth Van Der Veken,Gustaaf Henri Maria Willemsens
申请号：
US11661468
公开号：
US08563591B2
申请日:
2005.08.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, whereinX represents C or N；Y represents C or N；L represents a methyl or a direct bond；Z1 represents a direct bond, C1-2alkyl- or a divalent radical of formula —CH2—CH═ (a) or —CH═ (b)；Z2 represents a direct bond, C1-2alkyl- or a divalent radical of formula —CH2—CH═ (a) or —CH═ (b)；R1 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR3R4 or C1-4alkyl optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR5R6 or R1 represents C1-4alkyloxy- optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR7R8；R2 represents hydrogen, halo, C1-4alkyl or C1-4alkyloxy-；R3 and R4 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；R5 and R6 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；R7 and R8 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-；A represents phenyl or a monocyclic heterocycle selected from the group consisting of thiophenyl, furanyl, oxazolyl, thiazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyrridinyl, pyridazinyl, pyrimidinyl and piperazinyl.
