Compound represented by formula I, or a pharmaceutically acceptable salt or solvate thereof. wherein A represents a group of the formula in which Het represents a saturated or unsaturated five to seven membered heterocyclic group containing two nitrogen atoms selected from pyrimidyl, 1,4,5,6-tetrahydropyrimidyl, imidazolyl, tetrahydro [1 , 3] diazepinyl and imidazolidinyl, the heterocyclic group being optionally condensed with another saturated or unsaturated five or seven membered carbocyclic ring or heterocyclic ring forming benzimidazolyl or imidazo [4,5-b] pyridyl, the heterocyclic group and the optionally substituted bicyclic group being with C1-6 alkyl, amino, C1-6 alkoxy, C1-6 alkoxycarbonyl or aralkyl, with C1-6 alkyl, amino, C1-6 alkoxy, C1-6 alkoxycarbonyl and aralkyl optionally substituted with C1- alkyl 6 or C1-6 alkoxy； D represents>； NR4, in which R4 represents a hydrogen atom or C1-6 alkyl； X represents CH and Z represents N； R7 represents C1-6 alkyl, C1-6 alkoxy, a halogen atom, amino, nitro, hydroxyl or an oxygen atom, with C1-6 alkyl and C1-6 alkoxy optionally substituted with a halogen atom, C1- alkoxy 6, amino or hydroxyl； R8 represents C1-6 alkyl, C1-6 alkoxy, a halogen, amino, nitro or hydroxyl atom, with C1-6 alkyl and C1-6 alkoxy optionally substituted with a halogen atom, C1-6 alkoxy, amino or hydroxyl； Q represents>； C = O or>； CH2； R9 represents a hydrogen atom, C1-6 alkyl or aralkyl, the C1-6 alkyl and aralkyl being optionally substituted with a halogen atom, C1-6 alkoxy, amino or hydroxyl； R10 represents a hydrogen atom or C2-6 alkynyl； R11 represents a hydrogen or amino atom, the amino being optionally substituted with C1-6 alkyl, C16 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkyl sulfonyl, benzyloxycarbonyl, the phenyl portion being optionally substituted with C1 alkyl -6, C1-6 alkoxy, carboxyl, hydroxy, nitro, amino or a halogen atom, or benzenesulfonyl, the phenyl portion being optionally substituted with C1-6 alkyl, C1-6 alkox
