ГЛИВ Мартин Е. (CA),ЗУБЕЙДИ Амина (CA),ЛАМУРЕ Франсуа (FR)
申请号：
RU2013145869/15
公开号：
RU2013145869A
申请日:
2012.03.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating a mammal suffering from prostate cancer, comprising administering to the mammal i) an oligonucleotide which reduces the expression of clusterin, and ii) an inhibitor of heat shock protein 90 (Hsp90), having the structure: or a pharmaceutically acceptable salt gdeRpredstavlyaet is H, C -Calkil, C-Sgalogenalkil, C cycloalkyl, heterocycloalkyl, C-Catsil, aryl or heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl group is optionally substituted by 1 to 4 groups that are independently They represent C-Ci ^ alkyl, C-alkoxy, halogen, hydroxy, amino, mono- or di- (C-C) alkylamino, nitro, halo (C-C) alkyl, halo (C-C) alkoxy, or carboxamide, R gdekogda a C-Calkilnuyu group, up to five carbon atoms in the alkyl group are optionally replaced independently for R, carbonyl, ethenyl, ethynyl or a group selected from N, O, S, SOili SO, with the proviso that two O atoms, two atoms S or O and S atom are not attached directly to each other, a gdeRpredstavlyaet (i) heteroaryl, (ii) aryl, (iii) a saturated or unsaturated cycloalkyl or C (i v) saturated or unsaturated C Sgeterotsikloalkil wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl or saturated or unsaturated heterocycloalkyl are independently optionally substituted with at least one group that is independently hydroxy, halogen, amino, cyano, carboxy, carboxamido , nitro, oxo, -S- (CC) alkyl, -SO (C-C) alkyl, -SO-aryl, -SO- (CC) alkyl, -SO-aryl, -SONH, -SONH- (C-C ) alkyl, -SONH-aryl, (CC) alkoxy, or mono- or di- (C-C) alkylamino and Rneobyazatelno fused to the C-Sarilnoy group, C-cyclic groups Cnasyschennoy
