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Alpha-helix mimetics and method related to cancer stem cell treatment
专利权人:
CHOONGWAE PHARMA CORPORATION
发明人:
KAHN, Michael
申请号:
ES06844324
公开号:
ES2570994T3
申请日:
2006.11.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound having the general formula (VI): ** Formula ** where B is - (CHR2) -, E is - (CHR3) -, V is - (XR4) -, W is - (C>; = O ) - (XR5R6), X is nitrogen, and R1, R2, R3, R4, R5, and R6 is selected from an amino acid side chain structural unit or derivative thereof, wherein the derivative is a C1-12 alkyl, C6-12 aryl or C7-12 aryl straight or branched chain, cyclic or non-cyclic, substituted or unsubstituted, saturated or unsaturated, wherein the substituents are selected from one or more of: -OH, -OR, - COOH, -COOR, -CONH2, -NH2, -NHR, -NRR, -SH, -SR, -SO2R, -SO2H, -SOR and halogen, where R is a C1-12 alkyl, C6-12 aryl or C7 -12 aryl straight or branched chain alkyl, cyclic or non-cyclic, substituted or unsubstituted, saturated or unsaturated; and stereoisomers, and salts thereof, and wherein R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of aminoC2-5alkyl, guanidinoC2-5alkyl, C1-4alkylguanidinoC2-5alkyl, diC1-4alkylguanidino-C2 -5alkyl, C2-5alkyl, C1-4alkylaminoC2-5alkyl, diC1-4alkylaminoC2-5alkyl, C1-3alkoxy, phenyl, substituted phenyl (where the substituents are independently selected from one or more of amino, amidino, guanidino, hydrazino, amidrazonyl, C1 -4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl or hydroxyl), benzyl, substituted benzyl (where the benzyl substituents are independently selected from one or more than amino, amidino, guanidino, hydrazino, amidrazonyl, C1-4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl or hydroxyl), naphthyl, substituted naphthyl (where the substituents s and independently selected from one or more of amino, amidino, guanidino, hydrazino, amidrazonyl, C1-4alkylamino, C1-4dialkylamino, halogen, perfluoro C1-4alkyl, C1-4alkyl, C1-3alkoxy, nitro, carboxy, cyano, sulfuryl or hydroxyl ), bis-phenyl methyl, substituted bis-phenyl methyl (where the substituents
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