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Pyridine derivatives cb2 receptor agonists
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
MATTHIAS NETTEKOVEN,TANJA SCHULZ-GASCH,MARK ROGERS-EVANS,ERNST SCHAFFTER,UWE GRETHER,STEPHAN ROEVER,STEFANIE BENDELS,ATSUSHI KIMBARA
申请号:
ARP130104506
公开号:
AR093806A1
申请日:
2013.12.05
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
1. Claim 1: a formula compound (1),R1 is cyclododecalalcoxi, halogenated phenyl, tetrahydrofuran lalcoxi, halogenated phenyl, halogenated hydrocarbon, tar, tetrahydropyridol or halogen; R2 is tar, pyridylene, cyclopentadiene, cyclopentadienyl, cyclopentadienyl hydrazide, halogenated tar, cyclopentadienyl, hydroxy or haloxyethane; In this paper, the author analyzes the characteristics of(alkyloxadiazolyl) (cycloalkyl) alkyl, pyridazinylalkyl, aminocarbonylalkyl, alkyloxyadiazolylalkyl, alkyltetrazolylalkyl, formyl, phenyl, dialkylpyrazolyl, alkylcarbonylpiperidinyl or cycloalkylalkyl; or R³ and R⁴ together with the nitrogen atom, to which they are attached, form a substituted heterocyclyl or heterocyclyl; said heterocyclyl is 6-oxa-1-aza-spiro [3.3] heptyl, oxazolidinyl, morpholinyl, pyrrolidinyl, piperazinyl, 2-oxa-5-aza-spiro [3.4] octyl piperidinyl, 6-azabicyclo- [3.2.1] octyl, imidazolidinyl, 4-azaspiro [2.4] heptyl, 2-azabicyclo [2.2.1] heptyl, 2-thia-5-azabicyclo [2.2.1] heptyl, 2,5-diazabicyclo [2.2.1] heptyl, 2- oxa-5-azabicyclo [2.2.1] -heptyl,, 1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1 o [3.4] octabromodiphenyl ether, Azerbaijan, 5-aza-helix [2.4] heptabromide, 3-azabicycleo [3.1.0] - hexilo 5-aza-helix [2.4] hetilo, 1,3,3a, 4,6,6a-hexahydrofuro [3,4-c] - pyridine; the substituted isocyclohexane is one to four times the isocyclohexane substitute, which is composed of independent tar, oxy, hydroxy, anthrax, asphalt, tar, hydrocarbon, hydrogenated hydrogen, carbonate, carbonate, carbonate, carbonate and carbonate substitutes, Halogen, phenyl, phenyl,4. Alcoxico carbon, cyclo clalquilo, fenilalcoxicabonilo, cyclolaquilo, haloalquilo, hydroxielquilo and halotars, on the condition that R3 and r83088, together with the nitrogen atoms connected with them, do not form an unsubstituted pyridyl alcohol, an unsubstituted thiomolol, or an oxypyridyl alcohol; Or a salt or ester that is medically acceptable.Reivindicación 1: Un compuesto de la f
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