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Derivatives of 6 - (Buta - 1.3 - Diin - 1 - il) benzo [d] thiazole
专利权人:
IDORSIA PHARMACEUTICALS LTD.
发明人:
申请号:
ARP170101299
公开号:
AR108488A1
申请日:
2017.05.16
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
1. Claim 1: a formula compound (1),Among them, M is a (4-hydroxidin-1-il) carbide (3-hydroxidin-1-il) carbide or 1 - (methylamine) cycloacrylonitrile, or m is one of the Ma, MB, MC, MD, me and MF groups represented in formula group (2),XA1 represents methyl-d, methyl-d2, c8332131 / 832424;w-haloalkyl C₂₋₃,w-hydroxyalkyl C₂₋₄,2,3-dihydroxyprop-1-yl, 3-hydroxy-2- (hydroxymethyl) prop-1-yl, oxetane-3-yl, (oxetane-3-yl) methyl, tietan-3-yl, 1,1- dioxidothietan-3-yl, C₃₋₆ cycloalkyl,3-hidroxiciclobut-1-ilo 3- (w-hidroxialquil C) ciclobut-1-ilo tetrahidropiran-4-ilo cicloalquil C alquilo C o w-fosfonooxi-alquilo CXaa1 and xaa2 respectively represent h, i.e. rent c832131;a. Halogenated tar c833218d8333123 or hydroxyl c833218d833123;Xa3 is h, alkyl c8321c8331; or halogen; xb1 is c83218c8318324;w-hydroxyalkyl C₂₋₃,cycloalkyl C₃₋₆,1. Oxetan-3-ilo or tetrahydropiran-4-ilo; XB2 and XB2 respectively represent h, tar c833218331;a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;Xb31 and XB3 represent h, halogen, hydroxy and hydrocarbon c832138 respectively;a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;Xb83088 represents h, halogen, hydroxyl or c83218c8331;Xc1 for H, let c832131;cycloalkyl C₃₋₆,w-hydroxyalkyl C₂₋₃,1. Oxetan-3-ilo or tetrahydropiran-4-ilo; XC2 represents h, tar c83231;a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;Xc3 stands for H, halogen (especially fluorine)hydroxy, C₁₋₄-alkyl,a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;Xc830808 stands for H, lease land c833218331c83323;halogen or hydroxy; XD¹ represents H, C₁₋₄ alkyl,W-halo c833228d.833183323 or w-hydroxialquilo c83228331;Xd2 and xd3 represent h independently, lease land c832131;a. Halogenated tar c833218d833123 or hydroxyl c833218d833123;XE¹ represents H, C₁₋₄ alkyl,Halogenated tar c83218323;1, 2-dihydroxy or hydrogen peroxide;Xf1 for H, lease c832131;Halogenated tar c83218323;1, 2-dihydroxy or hydrogen peroxide;A V or W stands for... O-CH (OH) - o -CH -
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