This refers to 3-ureidoisoquinolin-8-yl derivatives of the formula (1) useful in prevention or treatment of bacterial diseases. Claim 1: A compound of the formula (1) wherein R¹ is C₁₋₃ alkyl,C₂₋₃ haloalkyl or cyclopropyl； R² is H, halogen, pyridazin-4-yl, pyrimidin-5-yl or a group having the formula (2),(3) Or (4),wherein Rˣ is H and each of Rʸ and Rᶻ is independently H or methyl, or each of Rˣ and Rᶻ is H and Rʸ is halogen, cyano, C₂₋₄ alkyl,C₁₋₄ alkoxy,amino hidroxi hidroxi-alquilo C3. Trifluoroide, carbamate, amino hydrocarbon c832138；(methylcarbamoyl) -C₁₋₂ alkyl,(dimethyl bromide) - c832131 asphalt；6. TERC butoxcarbonimetry, cyclophilo, pirrolidin-1-ilo, piperidin-1-ilo, morfolin-1-ilo or 1-morpolinometry, or r739es h and each r6966 and r7611a are independent halogen, or r739es methyl, r6966 or halogen and r7611es h, or r739s methyl or halogen, r6966 and r76h； Ethyl, formamide, methyl, methyl ethyl, formyl；； h and r696；； trimethyldimethylmethylmethylmethylmethylmethylmethylmethylacetamide, 1. Carbohydrate or carbamate, or r739b； 3 and r696； 3 It is h and r7611； 3 is hydroxyl；R³ is C₁₋₄ alkyl,1. C 83228331 asphalt；amino C₁₋₃ alkyl,carbamoyl-C₁₋₃ alkyl,(methylcarbamoyl) -C₁₋₃ alkyl,C₁₋₄ alkoxy,C₁₋₄ haloalkoxy,1. Asphalt c83223；(4-hidroxibut-2-en-1-il) oxi (4-aminobut-2-en-1-il) oxi dimetilamino-alcoxi Ccarbamoyl-C₁₋₃ alkoxy,C₁₋₃ alkylamino,C₃₋₆ cycloalkyl,C₃₋₆-C₁₋₄ cycloalkyl,C₃₋₆-C₁₋₄ alkoxycycloalkyl,hydroxy-C₁₋₃ alkyl,C₂₋₃ hydroxy-alkoxy,alcoxi C -alquilo CC₁₋₃ alkoxy-C₁₋₃ alkoxy,carboxy-C₁₋₃ alkyl,C₁₋₃ carboxy-alkoxy,C₁₋₂ alkoxycarbonyl-C₁₋₃ alkoxy,aryl, C₅₋₆ heteroaryl,bencilo benciloxi 2-cianoetoxi 2 3-dihidroxipropoxi 3 4-dihidroxibutoxi -CH R-CH₂CH₂Rᵇ,- (CH) -C (O) O-R(CH) -N (R) C (O) O-R-O- (CH) -N (R) C (O) O-R- (CH) -R o -O- (CH) -RN is 1, 2 or 3； r74919 is cyanogen, acetamide, N, N-dimethylamine； r749559 is cyanogen； r758080 is h or methyl； r74969 is c83224 asphalt；R74977；H or methyl； or salt of the compound.La presente se refiere a derivados de 3-u
