These compounds contribute to the treatment of diseases caused by skin 3K enzyme activity, such as arthritis, purple, allergy, hemocyte anemia, trypanosomiasis, leishmaniasis, toxemia. Claim 1: compound (1) or salt thereof of formula, wherein: selected from O or NH； V selected from cr83099 or N； W selected from ch832222；U. U is selected from n or CH； q is selected from n or cr8310；Where u and Q are not n, R1 is selected from phenyl, pyridine, pyridyl, pyridyl, pyridyl, peridol, pyridyl, 1,2,3-triazine, 1,2,4-Triazine, 1,3,5-triazine, o-x-r8308x, and X is selected from C (o)；S (O) ₂ or CH₂ and R⁴ is selected from C₁₋₈ alkyl,halo-alkyl Cilo,hydroxy-C₁₋₈-alkyl,C₁₋₈-alkoxy-C₁₋₈-alkyl,cyano-alkyl C₁₋₈,N, N-di-C₁₋₄-alkyl-amino-C₁₋₈-alkyl,1. C83218c83331c8324 sulfur tar c83321c83318328；phenyl, heterocyclyl, heterocyclyl-oxyl, heterocyclyl-C₁₋₈-alkyl,cycloalkyl C₃₋₁₂,C₃₋₁₂ cycloalkyloxy,C₃₋₁₂-cycloalkyl-C₁₋₈-alkyl,a. Abnormity, abnormity oxygen, abnormity tar c833218331；hydroxyl, C₁₋₈ alkoxy,amino, N-C₁₋₈-amino alkyl, or N, N-di-C₁₋₈-amino alkyl； wherein the C₁₋₈-alkyl in N-C₁₋₈-amino alkyl and in N, N-di-C₁₋₈-amino alkyl may be unsubstituted or substituted by halogen, hydroxyl, or C₁₋₄ alkoxy；wherein the C₃₋₁₂ cycloalkyl in C₃₋₁₂ cycloalkyl and in C₃₋₁₂ cycloalkyl-C₁₋₈ alkyl can be unsubstituted or substituted by 1 to 5 substituents selected from halogen, hydroxyl, or C₁₋₄ alkoxy；1. Acyclic hexane is a single ring system composed of 3 to 7 saturated or partially unsaturated members, which contains 1 to 3 heteroatoms selected from n or s, each of which has an unsaturated component, or is replaced by 1 to 5 substitutes selected from oxo, halogen, c832c83183288a；halo-alkyl Cilo,hydroxy-C₁₋₈-alkyl,hydroxyl, C₁₋₈ alkoxy,C₁₋₈-alkoxy-C₁₋₈-alkyl,a. 2008； isomerization can be combined in one isomerized atom or carbon atom, In this case, the heteroatoms of N and / or s can also be selectively oxidized to different oxidation states； heteromorphism is a single ring system consisting o
