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GRANULES À DISPERSION RAPIDE, COMPRIMÉS SE DÉLITANT ORALEMENT ET PROCÉDÉS AFFÉRENTS
专利权人:
ADARE PHARMACEUTICALS; INC.
发明人:
VENKATESH, GOPI M.,SWAMINATHAN, VIJAYA,LAI, JIN-WANG,CLEVENGER, JAMES M.
申请号:
EP11845725
公开号:
EP2646003A4
申请日:
2011.12.02
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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