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1,3-Dihydro-benzimidazol-2-ylidenoamines as inhibitors of respiratory syncytial virus replication
专利权人:
Janssen Sciences Ireland UC
发明人:
BONFANTI, Jean-François,FORTIN, Jérôme,DORANGE, Ismet
申请号:
ES06708798
公开号:
ES2574670T3
申请日:
2006.03.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound having the formula: ** Formula ** addition salts thereof or a stereochemically isomeric form thereof or a tautomeric form thereof; in which: each Alq is independently C1-6 alkanediyl; Q is hydrogen; C1-6 alkyl substituted with one or two Ar2 radicals; C1-6 alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl or with pyrrolidinonyl; -CO-Ar2 or Q is a radical of the formula: ** Formula ** in which t is 1, 2 or 3; R4 is amino, mono- or di (C1-6 alkyl) amino; R1 is quinolinyl; R2 is Ar2, -CO-Ar2, morpholinyl or quinolinyl; where Q is other than hydrogen, R3 is hydrogen or where Q is hydrogen, R3 is a radical of the formula: ** Formula ** in which: R6 is selected from hydrogen, C1-6 alkyl, Ar2 C1-6 alkyl, C1 hydroxyalkyl -6, (C 1-6 alkyl) -C 1-6 alkyl, C 1-6 aminoalkyl, mono- and di (C 1-6 alkyl) aminoC 1-6 alkyl, C 1-6 carboxylalkyl, C 1-6 alkylcarboxylalkylC 1-6 alkyl, C 1-6 aminocarbonylalkyl, mono- and di (C 1-6 alkyl) C 1-6 aminocarbonylalkyl; R7, R8, R9 independently are each selected from: halo, cyano, C1-6 alkyl, Ar1-C1-6 alkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 cyanoalkenyl, C2-6 alkynyl, C2 cyanoalkynyl -6, Ar1, R10a-O-, R10a-S-, - N (R5aR5b), C1-6 polyhaloalkyl, R10a-OC (>; = O) -, N (R5aR5b) -C (>; = O) -, R10a -O-C1-6 alkyl, N (R5aR5b) -C1-6 alkyl, R10a-OC (>; = O) -C1-6 alkyl, N (R5aR5b) -C (>; = O) -C1-6 alkyl, R10a -C (>; = O) -NR5b-, R10b-C (>; = O) -O-, R10b-C (>; = O) -C 1-6 alkyl and R8 and / or R9 may also be hydrogen; each R5a and R5b independently of each other are hydrogen or C1-6 alkyl; R10a is hydrogen, C1-6 alkyl or Ar1 C1-6 alkyl; R10b is C1-6 alkyl or Ar1 C1-6 alkyl; Ar1 is phenyl or phenyl substituted with 1, 2, 3 or 4 substituents independently selected from: halo, hydroxy, C1-6 alkyl, hydroxyalkyl C1-6, polyhaloalkyl C1-6 and alkyl C1-6oxy; Ar2 is phenyl or phenyl substituted with 1, 2, 3 or 4 substituents independently selected from: halo, hydroxy, C1-6 alkyl, cyano, nitro
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