JAROSKOVA, LIBUSE,贾诺可,賈諾可,LINDERS, JOANNES THEODORUS MARIA,林德斯,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,布克,VAN DER VEKEN, LOUIS JOZEF ELISABETH,樊德肯,DIMITROV, VLADIMIR DIMTCHEV,迪米夫,NIKIFO
申请号：
TW094114611
公开号：
TWI396534B
申请日:
2005.05.06
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
theN－oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2；L represents a C1－3alkyl linker optionally substituted with one or two substituents selected from C1－4alkyl, C1－3alkyloxy－C1－4alkyl－, hydroxy－C1－4alkyl, hydroxy, C1－3akkyloxy－or phenyl－C1－4alkyl；M represents a direct bond or a C1－3alkyl linker optionally substituted with one or two substituents selected from hydroxy, C1－4alkyl or C1－4alkyloxy；R1and R2each independently represent hydrogen, halo, cyano, hydroxy, C1－4alkyl optionally substituted with halo, C1－4alkyloxy－optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar1and halo；or R1and R2taken together with the phenyl ring to which they are attached form naphtyl or 1,3－benzodioxolyl, wherein said naphtyl or 1,3－benzodioxolyl are optionally substituted with halo；R3represents hydrogen, halo, C1－4alkyl, C1－4alkyloxy－, cyano or hydroxy；R4represents hydrogen, halo, C1－4alkyl, C1－4alkyloxy－, cyano or hydroxy；R5represents hydrogen, C1－4alkyl or Ar2－C1－4alky－；R6represents hydrogen, halo, C1－4alkyl or C1－4alkyoxy－；Ar1and Ar2each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C1－4alkyl, C1－4alkyloxy－, or phenyl－C1－4alkyl；for use as a medicine.本發明乃有關作為醫藥用途之具下式(I)之化合物其N－氧化物、醫藥上可接受之加成鹽及立體化學異構物型，其中n為1或2；L代表視需要被選自C1－4烷基、C1－3烷基氧基－C1－4烷基－、羥基－C1－4烷基、羥基、C1－3烷基氧基－或苯基－C1－4烷基之一或二個取代基取代之C1－3烷基連接基；M代表直接鍵或視需要被選自羥基、C1－4烷基或C1－4烷基氧基之一或二個取代基取代之C1－3烷基連接基；R1及R2各自獨立地代表氫、鹵基、氰基、羥基、視需要被鹵基取代之C1－4烷基、視需要被選自羥基、Ar1與鹵基之一個或需要時二或三個取代基取代之C1－4烷基氧基－；或R1與R2及和其連接的苯環一起形成萘基或1,3－苯并二環戊烯基，其中該萘基或1,3－苯并二環戊烯基視需要被鹵基取代；R3代表氫、鹵基、C1－4烷基、C1－4烷基氧基－、氰基或羥基；R4代表氫、鹵基、C1－4烷基、C1－4烷基氧基－、氰基或羥基；R5代表氫、C1－4烷基或Ar2－C1－4烷基－；R6代表氫、鹵基、C1－4烷基或C1－4烷基氧基－；Ar1及Ar2各自獨立地代表苯基或萘基，其中該苯基與萘基視需要被C1－4烷基、C1－4烷基氧基－、或苯基－C1－4烷基
