FELDING Jakob (DK),ФЕЛДИНГ Якоб (DK),NIL'SEN Simon Fel'dbek (DK),НИЛЬСЕН Симон Фельдбек (DK),FELDING JAKOB,ФЕЛДИНГ Якоб,NILSEN SIMON FELDBEK,НИЛЬСЕН Симон Фельдбек
申请号：
RU2009128191/04
公开号：
RU0002493149C2
申请日:
2007.12.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention describes a compound of formula I , in which X1, X2, X3, X4 and X5 independently denote -CH- or N； or X3, X4 and X5 independently denote -CH- or N, and X1 and X2 independently denote C and are part of an additional 6-member aromatic ring； in which R1 denotes methyl or ethyl, or R1 denotes hydrogen； R2 denotes methyl, ethyl, propyl, tert-butoxy carbonylmethyl, allyl, difluoromethyl, ethylbenzene, methylbenzene, butenyl, hydroxyethyl, tolyl, pentenyl, methoxyethyl, butynyl, propynyl, methylcarbonyloxy, cyclopentyl, each of which can be substituted with one or more identical or different substitutes selected from R5； or R2 denotes hydrogen； R3 denotes alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, halogenalkyl, hydroxyalkyl, heterocycloalkenyl, alkylaryl, arylalkyl, alkylalkoxycarbonyl, alkylcarbonyloxy or alkoxyalkyl, each of which can be substituted with one or more identical or different substitutes selected from R6； or R3 denotes hydrogen, -CH2-C(O)-heterocycloalkyl or -CH2-C(O)NR9-R12； R11 denotes one or more identical or different substitutes selected from hydrogen, halogen, cyano, amino, alkyl, methylthionyl, methylsulphonyl, amino, cyano or alkoxy； where R5, R6, R9, R12 are as indicated in claim 1, under the condition that R1, R2 and R3 cannot be methyl at the same time； under the condition that when R2 and R3 both denote hydrogen, R1 cannot be methyl or hydrogen； under the condition that when R1 denotes methyl or hydrogen, R2 denotes methyl and R3 denotes hydrogen when ring B cannot be phenyl； and pharmaceutically acceptable salts and N oxides thereof. The invention also describes a pharmaceutical composition for use in case of skin diseases, said composition containing a compound of formula I, and use of said compound in preparing a medicinal agent for preventing conditions associated with skin wounds.EFFECT: novel compounds which can be useful in treating skin diseases are obtained and described.19 cl, 304 exНастоя
