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New derivatives of 1-benzyl-3-hydroxymethylindazole and its use in the treatment of diseases based on the expression of CX3CR1 and p40
专利权人:
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
发明人:
GUGLIELMOTTI, Angelo,FURLOTTI, Guido,MANGANO, Giorgina,CAZZOLLA, Nicola,GAROFALO, Barbara
申请号:
ES09717638
公开号:
ES2637009T3
申请日:
2009.03.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** (See formula) ** in which: A can be -X1- or -X1-OC (R9) (R10) -, in which X1 can be an alkyl group having 1 at 5 carbon atoms, optionally substituted with one or more alkyl groups having 1 to 5 carbon atoms or one or more alkoxy groups having 1 to 3 carbon atoms, and R9 and R10, which may be identical or different with each other, they can be hydrogen, an alkyl group having 1 to 5 carbon atoms, or an alkoxy group having 1 to 3 carbon atoms, Y is OH R1 and R2, which can be identical or different from each other, they can be hydrogen, an alkyl group having 1 to 5 carbon atoms, or an alkoxy group having 1 to 3 carbon atoms, R3, R4 and R8, which can be identical or different from each other, can be hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 3 carbon atoms, a halogen atom, -OH, -N (R ') (R "), -N (R' ) COR ", -CN, -CONR'R", -SO2NR'R ", -SO2R ', nitro and trifluoromethyl; with R 'and R ", which may be identical or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms, R5 may be hydrogen, an alkyl group having 1 to 5 carbon atoms , an alkoxy group having 1 to 3 carbon atoms, a halogen atom, -OH, -N (R ') (R "), -N (R') COR", nitro and trifluoromethyl, or R5 together with one of R6 and R7 forms a ring having 5 or 6 carbon atoms; with R 'and R ", which may be identical or different from each other, represented by hydrogen and an alkyl group having 1 to 5 carbon atoms , R6 and R7, which may be identical or different from each other, may be hydrogen, an alkyl group having 1 to 5 carbon atoms, or together form a group C>; = O, or one of R6 and R7, together with R5, it forms a ring having 5 or 6 carbon atoms, with the proviso that when Y is -OH, A is different from an alkyl group having 1 carbon atom, optionally substituted with one or more alkyl groups having 1 to 5 carbon atoms, or alternatively at least one of the groups of R1 to R8 is different from hydrogen.Compuest
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