HITCHCOCK, STEPHEN,AMAGADZIE, ALBERT,QIAN, WENYUAN,XIA, XIAOYANG,HARRIED, SCOTT S.
申请号：
ES07796466
公开号：
ES2452822T3
申请日:
2007.06.26
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula (I): ** Formula ** in which: n is an integer from 1 to 3； R1 and R2 are independently selected from hydrogen, alkyl, haloalkyl, alkoxy, haloalkoxy, aryl, heteroaryl, cycloalkyl or heterocyclyl, in which the aforementioned rings are optionally substituted with Ra, Rb or Rc selected, independently, between alkyl, halo, haloalkyl, alkoxy, haloalkoxy, hydroxy, cyano, monosubstituted amino or disubstituted amino； or R1 and R2, when attached to the same carbon atom, can be combined to form saturated monocyclic cycloalkyl or heterocyclyl to give a spiro ring in which the monocyclic saturated cycloalkyl or heterocyclyl can be optionally substituted with selected Rd, Re or Rf, so independent, entrealkyl, alkoxy, fluoro, fluoroalkyl, fluoroalkoxy, hydroxy, monosubstituted amino or disubstituted amino； R1 and R2, when attached to the carbon atoms of positions 2 and 5 or 3 and 6 of the piperazine ring, can be combined to form the C1-C3 alkylene chain in which one of the chain carbon atoms of alkylene is optionally replaced by a -NR-, -O-, -S (O) n1- (in which R is hydrogen or alkyl and n1 is 0-2) and also in which one or two hydrogen atoms of the alkylene chain can be optionally substituted with one or two alkyls； R3, R4 and R5 are, independently, hydrogen, alkyl, fluoro or fluoroalkyl； and Ar1 and Ar2 are, independently, aryl, heteroaryl, cycloalkyl or heterocyclyl, in which each ring mentioned above is optionally substituted with Rg, Rh or Ri, where Rg is alkyl, -C>； = C-R6 ( in which R 6 is aryl or heteroaryl), halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, mono-substituted amino, disubstituted amino, sulfonyl, acyl, carboxy, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, hydroxyalkoxy, alkoxyalkoxy, alkoxyalkoxy , aminocarbonyl or acylamino, and Rh and Ri are selected, in an independent manner, from alkyl, halo, haloalkyl, haloalkoxy, alkylthio, cyano, alkoxy, amino, aminomonosubstituted, disubstituted amino, sulfonyl, acyl, ca
