НОВЫЕ ПРОИЗВОДНЫЕ 6-ТРИАЗОЛПИРИДИНСУЛЬФАНИЛ-БЕНЗОТИАЗОЛА ИЛИ -БЕНЗИМИДАЗОЛА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРИМЕНЕНИЕ ИХ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ
The invention relates to novel 6-triazolopyridazinesulfanyl benzothiazole or benzimidazole derivatives of formula (I)whereinrepresents a single or double bond； Ra represents a hydrogen atom； a Calkoxy radical optionally substituted with a chlorine atom, a hydroxyl radical or a heterocycloalkyl radical； a OCcycloalkyl radical； a heteroaryl radical optionally substituted with Calkyl； a phenyl radical optionally substituted with a halogen atom； an NHCOCalkyl or NR1R2 radical as defined hereinafter； X represents S； A represents NH or S； W represents a hydrogen atom； a Calkyl radical optionally substituted with a Calkoxy group or NR3R4； or a COR radical wherein R represents a Ccycloalkyl radical or a Calkyl radical optionally substituted with a Calkoxy group； a Calkoxy radical optionally substituted with NR3R4, Calkoxy or heterocycloalkyl； or O-phenyl； or an NR1R2 radical wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, a Ccycloalkyl radical, or a Calkyl radical optionally substituted with Calkoxy or an NR3R4 group, or R1 and R2 form, together with the nitrogen atom to which they are attached, a morpholinyl or piperazinyl group optionally substituted with one or more Calkyl groups； R3 and R4, which may be identical or different, represent a Calkyl radical, or R3 and R4 form, together with the nitrogen atom to which they are attached, a morpholinyl, piperazinyl or pyrrolidinyl group optionally substituted with one or more Calkyl groups； wherein a heterocycloalkyl radical represents a monocyclic or bicyclic carbocyclic radical containing from 3 to 10 members, interrupted with one or more heteroatoms chosen from O, N or S atoms； a heteroaryl radical represents an unsaturated or partially unsaturated, monocyclic or bicyclic, carbocyclic radical containing from 3 to 12 members which can optionally contain one or more heteroatoms, identical or different, chosen from O, N or S with N used as medicaments, in particular as MET inhibitors.Изобретение относится
