BRODNEY, MICHAEL,HELAL, CHRISTOPHER,O'NEILL, BRIAN
申请号：
ES09742523
公开号：
ES2375913T3
申请日:
2009.05.04
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I: wherein the stereochemistry shown in formula I in the carbon bonded to R2 and in the spirocyclic carbon is the absolute stereochemistry； B is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, in which B is optionally substituted with zero to three R4 groups； Z is (CH2) n-Op- (CH2) qo a cycloalkylene moiety, with the proviso that when Z is (CH2) n-Op- (CH2) q, the terminal methylene of the chain (CH2) n is attached to the piperidinyl ring nitrogen； A is independently aryl, cycloalkyl, heterocycloalkyl or heteroaryl, wherein said aryl, cycloalkyl, heterocycloalkyl, or heteroaryl group is optionally substituted with one to three R1； each R1 is independently alkyl, halogen, cyano, SO2NHR9, CON (R8) 2, N (R8) COR8, SO2N (R8) 2, N (R8) SO2R8, COR8, SO2R8, cycloalkyl- (CH2) r, heterocycloalkyl- ( CH2) t, aryl- (CH2) t, heteroaryl- (CH2) t, (CH2) tN (R9) 2 or (CH2) t-OR6 in which each R1 alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- ( CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted independently with cyano, alkyl, halogen or OR6； R2 is alkyl, cycloalkyl or alkenyl in which said alkyl, cycloalkyl or alkenyl is optionally substituted by halogen, hydroxyl or cyano； R3A and R3B are each independently hydrogen, aryl, heteroaryl or alkyl optionally substituted with R1； or R3A and R3B together with the carbon to which they are attached form a C = O, C = NR8, a cycloalkylene moiety or a heterocycloalkylene moiety； each R4 is independently halogen, hydroxyl, cyano, halo, O-alkyl, O-cycloalkyl, SO2R8, N (R8) 2, COR8, CON (R8) 2, alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t, wherein said R4 alkyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2) t, aryl- (CH2) to heteroaryl- (CH2) t is optionally substituted with R1； each R5 is independently hydrogen alkyl, alkenyl, cycloalkyl- (CH2) t, heterocycloalkyl- (CH2), aryl- (CH2) to heteroaryl- (CH2) t, wherein said substituent R5 alkyl, alkenyl, cycloalky
