Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation

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专利权人:

Stefan Hart;Axel Ullrich;Andreas Gschwind

发明人:

Axel Ullrich,Andreas Gschwind,Stefan Hart

申请号：

US12400122

公开号：

US08591903B2

申请日:

2009.03.09

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to the modulation of transactivation of receptor tyrosine kinases by G protein or G protein-coupled receptor (GPCR) mediated signal transduction in a cell or an organism comprising inhibiting the activity of the metalloprotease TACE/ADAM17 and/or the activity of the receptor tyrosine kinase ligand amphiregulin.

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