Bhide, Rajeev,Lombardo, Louis J.,Barbosa, Stephanie,Chai, Zhen-Wei,Qian, Ligang,Robl, Jeffrey
申请号：
HRP20050059
公开号：
HRP20050059B8
申请日:
2005.01.19
申请国别(地区):
HR
年份:
2016
代理人:
摘要：
The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.Predmetni izum se odnosi na spojeve formule (I) i njihove farmaceutski prihvatljive soli. Spojevi formule (I) inhibiraju aktivnost tirozin kinaze receptora faktora rasta kao što su VEGFR-2 i FGFR-1, što ih čini korisnim u liječenju karcinoma. Spojevi formule (I) su također korisni za liječenje drugih oboljenja povezanih sa putevima prijenosa signala koji djeluju preko receptora faktora rasta.
