자로스코바 리부스,린더 조앤 테오도러스 마리아,판 데르 베켄 루이스 조제프 엘리자베스,윌렘센스 거스타프 헨리 마리아,비스초프 프랑수아 폴
申请号：
KR1020077006712
公开号：
KR1011976740000B1
申请日:
2005.08.26
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents O, S, NR6, SO or SO2； R1 represents hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted with halo, R2 represents hydrogen, C1-4alkyl, or C1-4alkyloxy-； R3 represents hydrogen, C1-4alkyl, C1-4alkyloxy- or R3 combined with R2 form together a divalent radical selected from the group consisting of &mdash；O&mdash；CH2&mdash； (a), &mdash；NR7&mdash；CH2&mdash； (b), &mdash；(CR8R9)m- (c) and &mdash；CR10&boxH； (d) wherein m represents 1 or 2 and R7, R8, R9 and R10 are each independently selected from hydrogen or C1-4alkyl； R4 represents hydrogen, halo, hydroxy, cyano, amino, NR11R12, C1-4alkyloxy- optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R4 represents C1-4alkyl optionally substituted with one or where possible two or three substituents selected from hydroxy and halo； R5 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C1-4alkyloxycarbonyl, hydroxycarbonyl, NR13R14 or C1-4alkyl substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C1-4alkyloxy or NR15R16； R6 represents hydrogen； R11 and R12 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R13 and R14 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R15 and R16 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-； R17 and R18 each independently represent hydrogen, C1-4alkyl or C1-4alkylcarbonyl-.일반식 (I)의 화합물, 이의 N-옥사이드 형태, 약제학적으로 허용가능한 부가염 및 입체화학적 이성질체:상기식에서, n은 1, 2, 3, 또는 4이고；Z는 O, S, NR6, SO 또는 SO2를 나타내며；R1은 수소, 시아노, 하이드록시, 또는 할로로 임의로 치환된 C1-4알킬을 나타내고；R2는 수소, C1-4알킬, 또는 C1-4알킬옥시-를 나타내며；R3는 수소, C1-4알킬, C1-4알킬옥시-를 나타내거나, R2와 결합된 R3는 함께 -O-CH2- (a), -NR7-CH2- (b), -(CR8R9)m- (c) 및 -CR10= (d) (여기서, m은 1 또는 2를 나타내고, R7, R8, R9 및 R10은 각각 독립적으로 수소 또는 C1-4알킬 중에서 선택된다)로 구성되는 그룹 중에서 선택되는 2가 라디칼을 형성하고；R4는 수소, 할로, 하이드록시, 시아노, 아미노
