The invention relates to a lipid-based coating composition comprisinga. Lipid vesicles consisting ofi. 85-95 mol% of a phospholipid (A) having a phosphatidylcholine group；ii. 5-12 mol% of a PEGylated phospholipid (B)；iii. optionally 0-3 mol% of a lipophilic compound (C) other than lipids (A) and (B)；b. 0-5 wt% of a water-soluble additive (D)； andc. at least 95 wt% of water,wherein lipid vesicles having a number average size between 50 and 140 nm (measured according to dynamic light scattering) and wherein the lipid vesicle concentration ranges between 0.025 mg/ml and 2 mg/ml, and wherein the mol% of lipids (A), (B) and (C) is calculated relative to the total molar amount of lipids (A)+(B)+(C) in the lipid-based coating composition and wherein the wt% of water-soluble additive (D) is calculated relative to the weight of the total composition.
