Steven W. Andrews,Sean Aronow,James F. Blake,Barbara J. Brandhuber,Adam Cook,Julia Haas,Yutong Jiang,Gabrielle R. Kolakowski,Elizabeth A. McFaddin,Megan L. McKenney,Oren T. McNulty,Andrew T. Metcalf,D
申请号：
US15858240
公开号：
US10112942B2
申请日:
2017.12.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are compounds of the Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
