AVERY, Alaric James,PHADTE, Mangala Mahadev,SCUTT, James Nicholas,TAYLOR, John Benjamin,VINER, Russell Colin,WAILES, Jeffrey Steven
申请号：
ES12797857
公开号：
ES2599807T3
申请日:
2012.11.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I): ** Formula ** in which: X is methyl or chlorine； R1 is methyl or chlorine； R2 is hydrogen, methyl, ethyl, n-propyl, cyclopropyl, vinyl, ethynyl, fluorine, chlorine, bromine, methoxy, ethoxy or fluoromethoxy； R3, R4 and R5, independently of one another, are hydrogen, C1-C5 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C2 fluoroalkyl or C1-C3 alkoxy-C1-C3 alkyl； and R6 is: hydrogen； C1-C5 alkyl； C2-C4 alkenyl； C2-C4 alkynyl； R6AA-C≡C-CH2-； C1-C2 fluoroalkyl； C1-C3 alkoxy-C1-C3 alkyl； C1-C3-thio-C1-C3 alkyl； C1-C3 alkyl-sulfinyl-C1-C3 alkyl； C1-C3 alkyl-sulfonyl-C1-C3 alkyl； C3-C4 cycloalkyl； or a 4, 5 or 6 membered unsubstituted monocyclic heterocyclyl having an annular heteroatom independently selected from oxygen, sulfur and nitrogen, and attached to an annular carbon atom in the heterocyclyl； or R6 is Q- (CH2) m-CH (R7) -, where m is 0 or 1, and R7 is hydrogen or R7 and R5 together are a bond, and Q is an optionally substituted heterocyclyl as defined below. ； or R6 is Het-CH (R8) -, wherein R8 is hydrogen or R8 and R5 together are a bond, and Het is an optionally substituted heteroaryl as defined below； or R 6 is C 3 -C 6 cycloalkyl-C 1 -C 2 alkyl； or is C4-C6 cycloalkyl-substituted C1-C2-alkyl, in a cycloalkyl ring carbon atom that is not the ring carbon atom attached to the rest of -C1-C2 alkyl- and that is not directly linked to the atom of ring carbon attached to the rest of -C1-C2 alkyl-, with one or two ring substituents that are independently:>； = NO-R10, oxo (>； = O), C1-C4 alkoxy, C1-C2 haloalkoxy, 2 - (C1-C3 alkoxy) -ethoxy, C3-C5-oxycycloalkyl, (C3-C5 cycloalkyl) methoxy, C2-C3-CH2-oxy alkenyl, C1-C3 alkyl or C1-C2 fluoroalkyl； or benzyloxy in which the phenyl ring is optionally substituted with one or two substituents that are independently methyl, methoxy, C1 fluoroalkoxy, fluorine or chlorine； or R6 is benzyl optionally substituted on its phenyl ring with one or two substituents that are independently: cyano, -C≡C-R6A, -C (R6
