PROBLEM TO BE SOLVED: To provide a skin care preparation for preventing or improving the skin condition due to parakeratosis.SOLUTION: The skin care preparation contains cyclopeptide compounds shown in formula (1) [wherein Xaa1 and Xaa5 are each ceril, threonyl or thiosynyl Xaa2 is isoleucyl, valyl or leucyl Xaa3 and Xaa4 are each asparaginyl, glutaminyl, aspartyl or glutamyl Cys is cysteinyl and R1 is shown either in formula (II) or in formula (III) wherein n is an integer of 1 through 10 or in formula (III)].COPYRIGHT: (C)2012,JPO&INPIT【課題】不全角化を起因とする皮膚の状態を予防または改善する皮膚外用剤の提供。【解決手段】式(I):〔式中、Xaa1およびXaa5はセリル基、スレオニル基、チロシニル基、Xaa2はイソロイシル基、バリル基、ロイシル基、Xaa3およびXaa4はアスパラギニル基、グルタミニル基、アスパラチル基、グルタミル基、Cysはシステイニル基、R1は式(II):(式中、nは1~10の整数を示す)または式(III):(式中、nは1~10の整数を示す)〕の環状ペプチド化合物を含有する皮膚外用剤。【選択図】なし
