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6-substituted aminonicotinamides bearing a group containing OH as modulators of KCNQ2 / 3
专利权人:
Grünenthal GmbH
发明人:
LUCAS, Simon,KÜHNERT, Sven,BAHRENBERG, Gregor,SCHRÖDER, Wolfgang,KLESS, Achim
申请号:
ES13719386
公开号:
ES2605947T3
申请日:
2013.04.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Substituted compound of general formula (I), ** Formula ** where R1 represents an unsubstituted or mono- or polysubstituted aliphatic (C2-6) residue; a cycloaliphatic residue (C3-6) or a heterocycloaliphatic residue of 3 to 6 members, in each case unsubstituted or mono- or polysubstituted, and in each case optionally bridged through an aliphatic group (C1-4), which at its at the same time it may not be substituted or be mono- or polysubstituted; or represents OR6, where R6 represents an unsubstituted or mono- or polysubstituted (C1-6) aliphatic residue; or a cycloaliphatic (C3-6) unsubstituted or mono- or polysubstituted residue; R2 and R3 represent, independently of each other, H; F; Cl; Br; I; CN; CH2F; CHF2; CF3; OH; OCH2F, OCHF2; OCF3; SCF3; an aliphatic residue (C1-4), or an O-aliphatic residue (C1-4), the aliphatic residue (C1-4) may in each case not be substituted or be mono- or polysubstituted; or a cycloaliphatic (C3-6) residue or a 3- to 6-membered heterocycloaliphatic residue, in each case unsubstituted or mono- or polysubstituted; provided that at least one of R2 and R3 represents H or is linked through a carbon atom; R4 and R5 represent, independently of each other, H; CH2F; CHF2; CF3; an aliphatic residue (C1-4), the aliphatic residue (C1-4) may not be substituted or be mono- or polysubstituted; or a cycloaliphatic (C3-6) residue or a 3- to 6-membered heterocycloaliphatic residue, in each case unsubstituted or mono- or polysubstituted; with the proviso that, if R4 and / or R5 represents (n) a 3- to 6-membered heterocycloaliphatic residue, the 3 to 6-membered heterocycloaliphatic residue is linked through a carbon atom; or R2 and R3 and / or R4 and R5 in pairs, in each case independently of each other, together with the carbon atom that connects them, form a cycloaliphatic (C3-10) residue or a 3 to 10-membered heterocycloaliphatic residue, in each case unsubstituted or mono- or polysubstituted; and the respective remaining substituents of R2 and R3 repr
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