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6-amino-nicotinamides substituted as modulators of KCNQ2 / 3
专利权人:
Grünenthal GmbH
发明人:
KÜHNERT, Sven,BAHRENBERG, Gregor,KLESS, Achim,SCHRÖDER, Wolfgang,LUCAS, Simon
申请号:
ES11778520
公开号:
ES2678899T3
申请日:
2011.10.19
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Substituted compound of general formula (I-c) ** (See formula) ** where R1 represents an unsubstituted or mono- or polysubstituted (C1-10) aliphatic group; a cycloaliphatic group (C3-10) or a heterocycloaliphatic group of 3 to 10 members, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked by an aliphatic group (C1-8), which in turn can be unsubstituted or mono- or polysubstituted; aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked by an aliphatic group (C1-8), which in turn can be unsubstituted or mono- or polysubstituted; R2 represents CH3, C2H5, CH2-O-CH3 or OCH3; R4 represents an unsubstituted or mono- or polysubstituted (C1-10) aliphatic group; a cycloaliphatic group (C3-10) or a heterocycloaliphatic group of 3 to 10 members, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked by an aliphatic group (C1-8), which in turn can be unsubstituted or mono- or polysubstituted; aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted and in each case optionally linked by a bridge, preferably in each case linked by bridge, of an aliphatic group (C1-8), which in turn may be not substituted or mono- or polysubstituted; with the proviso that if R4 denotes a 3-10 membered heterocycloaliphatic group or a heteroaryl, the 3-10 membered heterocycloaliphatic group or the heteroaryl is linked via a carbon atom; R5 denotes H or an aliphatic group (C1-10), preferably an aliphatic group (C1-4), unsubstituted or mono- or polysubstituted; or R4 and R5 form, together with the nitrogen atom that connects them, an unsubstituted or mono- or polysubstituted 3 to 10 membered heterocycloaliphatic group, R6 represents an unsubstituted or mono- or polysubstituted aliphatic (C2-6) group with at least one substituent selected from the group consisting of F, Cl, OH,>; = O, an O-aliphatic group (C1), OCF3, where the aliphatic group (C1) is not su
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