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Azabicyclo [3.1.0] hexane derivatives useful as modulators of D3 dopamine receptors
专利权人:
GLAXO GROUP LIMITED
发明人:
ARISTA, LUCA,BONANOMI, GIORGIO,CAPELLI, ANNA MARIA,DAMIANI, FEDERICA,DI FABIO, ROMANO,GENTILE, GABRIELLA,HAMPRECHT, DIETER,MICHELI, FABRIZIO,TARSI, LUCA,TEDESCO, GIOVANNA,TERRENI, SILVIA
申请号:
ES08169935
公开号:
ES2380990T3
申请日:
2005.02.21
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein - G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl; - p is an integer in the range of 0 to 5; - R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4 alkyl, C1-4 halogenoalkyl, C1-4 alkoxy, C1-4 halogenoalkoxy, C1-4 alkanoyl; or corresponds to a group R5; - R2 is hydrogen or C1-4 alkyl; - R3 is C1-4 alkyl; - R4 is hydrogen, phenyl, heterocyclyl, a 5- or 6-membered heteroaromatic group or an 8 to 11-membered bicyclic group, any of which is optionally substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, n-C1-4 alkyl, halogen C1-4 alkyl, C1-4 alkoxy or C1-4 alkanoyl; - R5 is a moiety selected from the group consisting of: isoxazolyl, -CH2-N-pyrrolyl, 1,1-dioxide-2-thiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and said group is optionally substituted with one or two substituents selected from: halogen, cyano, C1-4 alkyl, halogen C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl; and when R1 is chlorine and p is 1, said R1 is not present in the ortho position with respect to the binding bond with the rest of the molecule; and when R1 corresponds to R5, p is 1.Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo, en la que - G se selecciona de un grupo que consiste en: fenilo, piridilo, benzotiazolilo, indazolilo; - p es un número entero en el intervalo de 0 a 5; - R1 se selecciona independientemente de un grupo que consiste en: halógeno, hidroxi, ciano, alquilo C1-4, halogenoalquilo C1-4, alcoxi C1-4, halogenoalcoxi C1-4, alcanoilo C1-4; o corresponde a un grupo R5; - R2 es hidrógeno o alquilo C1-4; - R3 es alquilo C1-4; - R4 es hidrógeno, fenilo, heterociclilo, un grupo heteroaromático de 5 ó 6 miembros o un grupo bicíclico de 8 a 11 miembros, cualquiera de los cuales está sustituido opcionalmente con 1, 2, 3 ó 4 sustituyentes seleccionados del grupo
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