LAWRENCE LIVERMORE NATIONAL SECURITY, LLC;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
Sally J. DeNardo,Gerald L. DeNardo,Rodney L. Balhorn
申请号：
US16289464
公开号：
US20190262364A1
申请日:
2019.02.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
