Sally J. Denardo,Gerald L. Denardo,Rodney L. Balhorn
申请号：
US12988801
公开号：
US09884070B2
申请日:
2009.04.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
