THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
DEISSEROTH, KARL A.,TYE, KAY M.,WARDEN, MELISSA R.
申请号：
EP13765207
公开号：
EP2827707A4
申请日:
2013.03.13
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light-responsive opsin in a neuron of the animal are provided. The animal models are useful for identifying agents and targets of therapeutic strategies for treatment of depression. Examples of using the non-human animals expressing light-responsive opsin including Halorhodopsin family of light-responsive chloride pumps and Channelrhodopsin family of light-responsive cation channel proteins are described.
