REINHARDT, JOEL C.,MACDONALD, LYNN,TORRES, RICHARD,MORRA, MARC R.,MARTIN, JOEL H.
申请号：
CA2695997
公开号：
CA2695997C
申请日:
2008.08.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A human antibody or antigen-binding fragment of an antibody which specificallybinds human nerve growth factor(NGF) with KD of 5 pM or less, does not cross-react with neurotrophin-3 (NT-3), and binds human NGF with a KD of about 2 toabout 10-fold higher than the antibody or fragment binds rat and mouse NGF.The antibodies are useful in treating pain, includinginflammatory pain, post-operative incision pain, neuropathic pain, fracturepain, osteoporotic fracture pain, post-herpetic neuralgia,osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums,gout joint pain, as well as diseases, such as hepatocellularcarcinoma, breast cancer, and liver cirrhosis.
