MACDONALD, LYNN,TORRES, RICHARD,MORRA, MARC R.,MARTIN, JOEL H.,REINHARDT, JOEL C.
申请号：
MYPI 2010000492
公开号：
MY153781A
申请日:
2008.08.08
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
A HUMAN ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF AN ANTIBODY WHICH SPECIFICALLY BINDS HUMAN NERVE GROWTH FACTOR (NGF) WITH KD OF 5 µM OR LESS, AS MEASURED BY SURFACE PLASMON RESONANCE, WHEREIN THE ANTIBODY OR FRAGMENT THEREOF BINDS HUMAN NGF WITH AN AFFINITY OF ABOUT 2-10-FOLD HIGHER THAN THE ANTIBODY OR FRAGMENT BINDS RAT AND MOUSE NGF. THE ANTIBODIES ARE USEFUL IN TREATING PAIN, INCLUDING INFLAMMATORY PAIN, POST-OPERATIVE INCISION PAIN, NEUROPATHIC PAIN, FRACTURE PAIN, OSTEOPOROTIC FRACTURE PAIN, POST-HERPETIC NEURALGIA, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, CANCER PAIN, PAIN RESULTING FROM BURNS, GOUT JOINT PAIN, AS WELL AS DISEASES, SUCH AS HEPATOCELLULAR CARCINOMA, BREAST CANCER, AND LIVER CIRRHOSIS.
