Joel C. Reinhardt;Richard Torres;Joel H. Martin;Lynn MacDonald;Marc R. Morra
发明人:
Lynn MacDonald,Richard Torres,Marc R. Morra,Joel H. Martin,Joel C. Reinhardt
申请号：
US13406734
公开号：
US08613927B2
申请日:
2012.02.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
