BENZOPIRANO DERIVATIVES SUBSTITUTED WITH SECONDARY AMINES THAT INCLUDE IMIDAZOL GROUPS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
YI, KYU YANG,LEE, SUN KYUNG,YOO, SUNG-EUN,SUH, JEE HEE,KIM, NAK JEONG,HWANG, SUN KYUNG,LEE, BYUNG-HO,SEO, HO WON,LEE, CHONG OCK,CHOI, SANG-UN
申请号：
ES03784665
公开号：
ES2372486T3
申请日:
2003.07.30
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Benzopyran derivatives substituted with secondary amines containing imidazole groups, according to formula 1 below, their stereochemical isomers and pharmaceutically acceptable salts； wherein: R 1 represents H, CN, NO2 or NH2； R 2 represents in which R a represents a linear or branched alkyl group of 1 to 4 carbon atoms； R3 and R4 are independent of each other and both represent H, Cl, Br, F, an alkyl group of 1 to 3 carbon atoms, OR b, CF3, OCF3, NO2, or CO2R b, R b represents H or an alkyl group from 1 to 3 carbon atoms； and * represents a chiral center.Derivados benzopirano sustituidos con aminas secundarias que contienen grupos imidazol, según la fórmula 1 siguiente, sus isómeros estereoquímicos y sus sales farmacéuticamente aceptables； en la que: R 1 representa H, CN, NO2 o NH2； R 2 representa en la que R a representa un grupo alquilo lineal o ramificado de 1 a 4 átomos de carbono； R3 y R4 son independientes entre sí y ambos representan H, Cl, Br, F, un grupo alquilo de 1 a 3 átomos de carbono, OR b , CF3, OCF3, NO2, o CO2R b , R b representa H o un grupo alquilo de 1 a 3 átomos de carbono； y * representa un centro quiral.
