This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I) a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is optionally substituted lower alkyl, Y is -S(O) n - wherein n is 1 or 2, or -CO-, R 2 is hydrogen or lower alkyl, R 7 is hydrogen or lower alkyl, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.一種食慾抑制劑或抗肥胖藥,含有如下式(I)化合物、彼等之製藥容許鹽或彼等之溶劑合物:[R1為可有取代基之低烷基,Y為-S(O)n(n為1或2)或-CO-,R2為氫或低烷基,R7為氫或低烷基,X為低伸烷基、低伸烯基、伸芳基或環伸烷基等,Z為低烷基、可有取代基之烴環式基或可有取代基之雜環式基等]。
