YAN CHEN,JEFFREY ALLEN CAMPBELL,XIANGDONG ALAN WANG,LI SUN,SING QIANG - SIT,NY YUEN - SIN,PAUL MICHEL SCOLA,PIYASENA HEWAWASAM,ANDREW CHARLES GOOD
申请号：
ARP130101165
公开号：
AR090649A2
申请日:
2013.04.11
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
A compound having the formula (1) wherein: (a) R¹ is C₁₋₈ alkyl,C₃₋₇ cycloalkyl,or C₄₋₁₀ alkylcycloalkyl；(b) M is 1 or 2； (c) n is 1 or 2； (d) r 2 is h-rental c832131；C₂₋₆ alkenyl or C₃₋₇ cycloalkyl,each optionally substituted with halogen； (e) R³ is C₁₋₈ alkyl optionally substituted with halo, cyano, amino, C₁₋₆ dialkylamino,aryl C₆₋₁₀,C₇₋₁₄ alkylaryl,C₁₋₆ alkoxy,carboxy, hydroxy, aryloxy, C₇₋₁₄ alkyloxy,C₂₋₆ alkyl ester,Cil alkylaryl ester；C₃₋₁₂ alkenyl,C₃₋₇ cycloalkyl,or C₄₋₁₀ alkylcycloalkyl,There, bicycle or liquid tar can replace hydrogen Xi, asphalt c833218331；C₂₋₆ alkenyl or C₁₋₆ alkoxy；or R³ together with the carbon atom to which they are placed, forms a C₃₋₇ cycloalkyl group optionally substituted with C₂₋₆ alkenyl；(F) Y es H fenilo substituido con nitro piridilo substituido con nitro o alquilo C opcionalmente substituido con ciano OH o cicloalquilo Cprovided that if R⁴ or R⁵ is H then Y is H； (g) B is H, C₁₋₆ alkyl,R - (C 3DO) -R O (C 3DO) -R -N (R) -C (3DO)-R -N (R) -C (3DS) -R⁴SO₂-,o R -N (R) -SO -(h) R⁴ is (i) C₁₋₁₀ alkyl optionally substituted with phenyl, carboxyl, C₁₋₆ alkanoyl,1-3 halogen, hydroxy, -OC (O) C₁₋₆ alkyl,C₁₋₆ alkoxy,e. Substituting amino acid calcium c833218331 and 832626；Amido, O (low level)； (II) cycloquilo c83231cycloalkoxy C₃₋₇,or C₄₋₁₀ alkylcycloalkyl,each optionally substituted with hydroxy, carboxyl, (C₁₋₆ alkoxy) carbonyl, amino optionally substituted with C₁₋₆ alkyl,starch, the (lower alkyl) starch； (iii) aryl C₆₋₁₀ arylalkyl C₇₋₁₆,each optionally substituted with C₁₋₆ alkyl,a Halogen, nitrogen, hydroxyl, acyl two (lower) acyl ammonia, or alternative ammonia；(Iv) Het (v) biciclo (1 1 1) pentano o (vi) -C (O) O-alquilo Ca. Alquenilo c832283316a or c832283316a；(i) R⁵ is H； C₁₋₆ alkyl optionally substituted with 1-3 halogens； or C₁₋₆ alkoxy provided that R⁴ is C₁₋₁₀ alkyl；(j) X is O, s, so832222；-8.8322CH₂O or NH； (k) R is Het； or aryl C₆₋₁₀ or alkylaryl C₇₋₁₄,a. Replace r74919；and (l) Rᵃ is C₁₋₆ alkyl,C₃₋₇ cycloalkyl,C₁₋₆ alkoxy
