KIM, Soon Ha,KIM, Hyoung Jin,KOO, Sun Young,CHUNG, Chul Woong,LEE, Sung Bae,PARK, Heui Sul,YOON, Seung Hyun,KWAK, Hyo Shin,SEO, Dong Ook,PARK, Eok
申请号：
ES08793298
公开号：
ES2691068T3
申请日:
2008.08.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Indole compounds of the following Formula (1): ** Formula ** in which n denotes a number from 1 to 3, m is 1, A represents phenyl, X represents C, R1 represents hydrogen, alkyl, - (CH2) rNR7R8, or - (CH2) rCO2H, where r denotes a number from 1 to 5, and R7 and R8 independently of each other represent hydrogen, alkyl or alkylcarbonyl, or can together form an alkylene chain optionally substituted with alkyl where optionally a Methylene is replaced by an atom of N, R2 represents hydrogen, halogen, cyano, nitro, alkyl, alkoxy or trialkylsilyl, represents - (CH2) pCO2R7, - (CH2) pOR7, - (CH2) pNR7R8, -NHR10, -N ( H) S (O) 2R7, -NHC (O) R10, - (CH2) pS (O) 2R7 or (CH2) p-heterocycle-R10, where p denotes a number from 0 to 3, the heterocycle is 3 -10 members and has 1-3 heteroatoms selected from N, O and S, R7 and R8 are as defined above, R10 represents hydrogen, oxo, alkylsulfonyl, alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl, alkoxy, alky the 3-10 membered heterocycle having 1 to 3 heteroatoms selected from N, O and S, R3 represents hydrogen, cyano, halogen, alkyl or phenyl, or represents- (CH2) n-heterocycle or - (CH2) n- aryl, where n denotes a number from 0 to 3 and the heterocycle is 3-10 members and has 1 to 3 heteroatoms selected from N, O and S, R4 represents -YR11, where Y represents a direct bond or - ( CR7R8) pY'-, where p denotes a number from 0 to 3, R7 and R8 are as defined above, Y 'is selected from the group consisting of -O-, -S-, -NR12-, - NR12C (O ) -, -C (O) -, -C (O) O -, - C (O) NR12-, -S (O) q-, and -S (O) qNR12-, where R12 represents hydrogen, alkyl , 3-10-membered aryl or heteroaryl having 1 to 3 heteroatoms selected from N, O and S, which denotes a number from 0 to 2, R11 is selected from the group consisting of hydrogen, cyano, halogen, hydroxy, thiol, carboxy, alkyl and - (CH2) tB-R13, where t denotes a number from 0 to 3, B represents 3-10 membered heterocycle having 1 to 3 heteroatoms selected from N, O and S, 3-10 membered heteroaryl
