BURSULAYA, Badry,FISCHER, Andreas,LAJINESS, James Paul,MACHAUER, Rainer,MALEKAR, Swapnil,PETRASSI, Hank Michael James,RAMAZANI, Farshad,REMOND, Anne-Catherine,ULLRICH, Thomas,USSELMANN, Peggy,VANGREVE
申请号:
PE2019000680
公开号:
PE20190657A1
申请日:
2017.09.21
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
It refers to indazol de conduct (I) compounds in the form of free or acceptable salts for drugs, in which R1 is selected from 1-C3 tar, halogen and alcoxi C1-C3; R2 is selected from 1-C3 and halogen; N is 1 or 2; R3 is H or tar 1-C3; R4 is optional cyclopropyl-C4-C6. It's for you. The selected compound is 1 - ((4 - (3 - Amino - 4 - methyl - 1H - indazol - 5 - il) - 3 - chlorophenyl) dinitro - 3 - methanol. In addition, it provides methods for processing these compounds and their use in muscle injury and/or ligation.Referido a compuestos de indazol de formula (I) en forma libre o en forma de sal farmaceuticamente aceptable, en donde R1 se selecciona de alquiloC1-C3, halogeno y alcoxi C1-C3; R2 se selecciona entre alquiloC1-C3 y halogeno; n es 1 o 2; R3 es H o alquiloC1-C3; y R4 es cicloalquiloC4-C6 opcionalmente sustituido. Un compuesto seleccionado es 1-((4-(3-amino-4-metil-1H-indazol-5-il)-3-clorofenil)sulfonil)pirrolidin-3-ol. Ademas, proporciona metodos para elaborar dichos compuestos y su uso en lesiones de tendones y/o ligamentos.