BROWN, Giles Albert,CANSFIELD, Julie Elaine,CONGREVE, Miles Stuart,O'BRIEN, Michael Alistair,PICKWORTH, Mark,RACKHAM, Mark David,TEHAN, Benjamin Gerald,TEOBALD, Barry John,BROWN GILES ALBERT,CANSFIELD JULIE ELAINE,CONGREVE MILES STUART,OBRIEN, Michael Alistair,OBRIEN MICHAEL ALISTAIR,PICK
申请号：
ES15703826
公开号：
ES2688548T3
申请日:
2015.02.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (1b): ** Formula ** or a salt thereof, wherein Q is an optionally substituted five or six or seven-membered heterocyclic ring containing 1,2, 3 or 4 heteroatom ring members selected of N, O and S； wherein Q may be substituted with one, two or three substituents, which may be selected from R1 and / or R2 where R1 and R2 may be the same or different or Q may be substituted with (L) -R10, (L) -R11 and (L) -R12, where L is a bond or a CH2 group； R10, R11 and R12 are independently selected from hydrogen； fluorine； chlorine； bromine； cyano； oxo； hydroxy； OR15； NR15R16； COR15； CSR15； COOR15； COSR15； OCOR15； NR17COR15； CONR15R16； CSNR15R16； NR17CONR15R16； R17COOR15； OCONR15R16； SR15； SOR15 and SO2R15； a C1-6 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, the carbon atoms of the hydrocarbon group may optionally be substituted by a heteroatom selected from O, N and S and oxidized forms thereof； and an optionally substituted 5 or 6 member ring containing 0.1, 2 or 3 heteroatoms selected from O, N and S and oxidized forms thereof, wherein the optional substituents for the optionally substituted 5 or 6 member ring are select from group R8； R1 is selected from hydrogen； fluorine； chlorine； bromine； cyano； oxo； hydroxy； OR5； NR5R6； COR5； COOR5； OCOR5； NR7COR5； CONR5R6； NR7CONR5R6； NR7COOR5； OCONR5R6； SR5； SOR5 and SO2R5； a C1-6 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, the carbon atoms of the hydrocarbon group may optionally be substituted by a heteroatom selected from O, N and S and oxidized forms thereof； and an optionally substituted 5 or 6 member ring containing 0, 1, 2 or 3 heteroatoms selected from O, N and S and oxidized forms thereof, wherein the optional substituents for the optionally substituted 5 or 6 member ring are select from group R8； R2 is selected from hydrogen； fluorine； c
