IDENIX PHARMACEUTICALS, INC.;UNIVERSITA DEGLI STUDI DI CAGLIARI
发明人:
SOMMADOSSI, JEAN-PIERRE,LACOLLA, PAOLO
申请号：
ES10183341
公开号：
ES2531011T3
申请日:
2001.05.23
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A composition for use in a method for the treatment or prophylaxis of a hepatitis C virus infection in a host comprising: an effective amount of a compound of Formula II: ** Formula ** or a pharmaceutically acceptable salt thereof , wherein the method further comprises administering one or more other antivirally effective agents, wherein: R1, R2 and R3 are independently H, phosphate； acyl； I rent； sulfonate ester including alkyl or arylalkyl sulfonyl, including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents selected from the group consisting of hydroxyl, amino, alkylamino, arylamino, alkoxy, aryloxy, nitro； cyano, sulphonic acid, sulfate, phosphonic acid, phosphate or phosphonate, unprotected or protected； a lipid, including a phospholipid； an amino acid； a carbohydrate； a peptide； a cholesterol； or another pharmaceutically acceptable leaving group that when administered in vivo is capable of providing a compound wherein R1, R2 and R3 are independently H or phosphate； Y is hydrogen, bromine, chlorine, fluorine, iodine, OR4, NR4R5 or SR4； X1 and X2 are independently selected from the group consisting of H, straight chain, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, chlorine, bromine, fluorine, iodine, OR4, NR4R5 or SR4； and R4 and R5 are independently hydrogen, acyl or alkyl (including, but not limited to, methyl, ethyl, propyl and cyclopropyl)； or an effective amount of a compound of Formula V: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein the method further comprises administering one or more other antivirally effective agents, wherein: R1, R2 and R3 are independently H, phosphate； acyl； I rent； sulfonate ester including alkyl or arylalkyl sulfonyl, including methanesulfonyl and benzyl, wherein the phenyl group is optionally substituted with one or more substituents selected from the group consisting of hydroxyl, amino, alkylamino, arylamino, alkoxy, aryloxy, nitro
