RABOISSON, PIERRE JEAN-MARIE BERNARD,罗宾森,羅賓森,DE KOCK, HERMAN AUGUSTINUS,德卡克,德卡克,MC GOWAN, DAVID CRAIG,麦大卫,麥大衛,VAN DE VREKEN, WIM,文德肯,文德肯,HU, LILI,胡丽丽,胡麗麗,TAHRI, ABDELLAH,塔亨利,塔亨利,VENDEVILLE, SANDRINE M
申请号：
TW096143432
公开号：
TWI406660B
申请日:
2007.11.16
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Inhibitors of HCV replication of formula (I)and the salts and stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond X is N, CH and where X bears a double bond it is C R1is -OR7, -NH-SO2R8 R2is hydrogen, and where X is C or CH, R2may also be C1-6alkyl R3is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl n is 3, 4, 5, or 6 R4is C1-6alkyl or C3-7cycloalkyl R5is hydrogen, halo, C1-6alkyl, hydroxy, C1-6alkoxy, polyhaloC1-6alkyl R6is hydrogen, C1-6alkoxy, mono- or diC1-6alkylamino or R5and R6may form a 5- or 6-membered unsaturated or partially unsaturated ring, optionally comprising one or two selected from O, N and S R7is hydrogen C3-7cycloalkyl optionally substituted with C1-6alkyl or C1-6alkyl optionally substituted with C3-7cycloalkyl R8is C3-7cycloalkyl optionally substituted with C1-6alkyl C1-6alkyl optionally substituted with C3-7cycloalkyl or -NR8aR8b R8aand R8bare C1-6alkyl, or both may form a 5- or 6-membered sturated heterocyclic ring pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).式(I)之HCV複製抑制劑及其鹽及立體異構物,其中各虛線(以-----表示)係表示視情況存在之雙鍵;X係為N、CH且當X帶有雙鍵時其係為C;R1係為-OR7、-NH-SO2R8;R2係為氫,且當X係為C或CH時,R2亦可為C1-6烷基;R3係為氫、C1-6烷基、C1-6烷氧基C1-6烷基、C3-7環烷基;n係為3、4、5或6;R4係為C1-6烷基或C3-7環烷基;R5係為氫、鹵基、C1-6烷基、羥基、C1-6烷氧基、多鹵基C1-6烷基;R6係為氫、C1-6烷氧基、單-或二C1-6烷基胺基;或R5及R6可形成5-或6-員不飽和或部分不飽和環,視情況包含一或兩個選自O、N及S者;R7係為氫;視情況經C1-6烷基取代之C3-7環烷基;或視情況經C3-7環烷基取代之C1-6烷基;R8係為視情況經C1-6烷基取代之C3-7環烷基;視情況經C3-7環烷基取代之C1-6烷基;或-NR8aR8b;R8a及R8b係為C1-6烷基或兩者可形成5-或6-員飽和雜環性環;含有化合物(I)之醫藥組成物及製備化合物(I)之方法。
