PIERRE JEAN-MARIE BERNARD RABOISSON,HERMAN AUGUSTINUS DE KOCK,DAVID CRAIG MC GOWAN,WIM VAN DE VREKEN,LILI HU,ABDELLAH TAHRI,SANDRINE MARIE HELENE VENDEVILLE
申请号：
BRPI0718798
公开号：
BRPI0718798A2
申请日:
2007.11.16
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
Inhibitors of HCV replication of formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by represents an optional double bond； X is N, CH and where X bears a double bond it is C； R1 is -OR7, -NH-SO2R8； R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl； R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl； n is 3, 4, 5, or 6； R4 is C1-6alkyl or C3-7cycloalkyl； R5 is hydrogen, halo, C1-6alkyl, hydroxy, C1-6alkoxy, polyhaloC1-6alkyl； R6 is hydrogen, C1-6alkoxy, mono- or diC1-6alkylamino； or R5 and R6 may form a 5- or 6-membered unsaturated or partially unsaturated ring, optionally comprising one or two selected from O, N and S； R7 is hydrogen； C3-7cycloalkyl optionally substituted with C1-6alkyl； or C1-6alkyl optionally substituted with C3-7cycloalkyl； R8 is C3-7cycloalkyl optionally substituted with C1-6alkyl； C1-6alkyl optionally substituted with C3-7cycloalkyl； or -NR8aR8b； R8a and R8b are C1-6alkyl, or both may form a 5- or 6-membered saturated heterocyclic ring； pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
