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Inhibiteurs macrocycliques du virus de l'hépatite C
专利权人:
Janssen Sciences Ireland UC;MEDIVIR AB
发明人:
申请号:
EP15158049.5
公开号:
EP2937339A1
申请日:
2006.07.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
Combinations comprising inhibitors of HCV replication of formula (I)and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond;Xis N, CH and where X bears a double bond it is C;R1is -OR7, -NH-SO2R8;R2is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl;R3is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl;R4is aryl or Het; n is 3, 4, 5, or 6;R5is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het;R6is C1-6alkoxy, or dimethylamino;R7is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;R8is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het;arylis phenyl optionally substituted with one, two or three substituents;Hetis a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents.
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