This refers to espirocarbamato analogs, Pharmaceutical compositions containing them and their use as TRPV4 antagonists.Claim 1: a compound of formula (1), in which R1 is Hydrogen, alkyl c1-3, CH2OH - or - CH3, CH2, ch2och2ph, ch2cn, CN, Halo or C (or whatever) OCH3； R2 is Hydrogen, CN, CF3, Halo, SO2 c1-3 alkyl, c1-3 alkyl or c u00bach； R3 is Hydrogen, alkyl c1-2, CF3 or Oh； R4 is Hydrogen,Halo or c1-3 alkyl； X is CR4 or N； n - (CH2) is het； or is (N - (CH2) crarb) - (CH2) M - Het； ra is Hydrogen or alkyl c1-3 alkyl in the C1 - 3 can be replaced with one additionally or more halos； RB is c1-3 alkyl or ra and RB, together with the carbon Atom to which they are UnitedForm a cycloalkyl Group C3 - 6； one or more of the carbon Atoms in the C3 6 cycloalkyl group formed by RA and RB can be replaced with Oxygen to form a oxetano, tetrahidrofurilo or tetrahidropiranilo； one of the carbon Atoms in the C3 - cycloalkyl group formed by RA and 6 RbCan be replaced with nitrogen to form a Group pirrolidinilo or piperidinilo； Het is selected from the group of formulas (2), in which het can be replaced with two or three substituents selected from: Halo, c1-5 alkyl, CN, CF3, CH2f, CHF2 cycloalkyl, c3-6, N - (CH2) or - alqui The C1 - (CH2) 3, N - phenyl - (CH2) piridilo, pirimidinilo, pirazinilo, CH (CH3) - alkyl - or - C1 3CH (OH) - c1-5 alkyl, - C (CH3) 2), C (o) n (CH3) P (c1-3 alkyl, n p), C (o) NH2, oxetano - CH3, NH2, oxetano, Tetrahydrofurfuryl, tetrahidropiranilo, morfolinilo or pirazolilo； in which the Substituent pirazolilo, phenyl, and piridilo in het can additionally be replaced with one or two substituents Selected from: Halo, CN, OCH3,C1-3 alkyl or Cf3 Substituent alkyl and cycloalkyl C3 and C1 - 5 - 6 in the het can be also replaced with cn or Oh； R5 is CN, or c1-4 alkyl, (CH2) M - (CH2) P - or - C (o) - or - alkyl C1 - 5 - (CH2) or P - or - R6； R6 is c1-4 alkyl or P (OR) 2 (CH3) 2 independently； n is 0, 1 or 2 m is independent； Entemente 0, 1 or 2； whether p is 1 or 2；
