DEAN, David Kenneth,MUNOZ-MURIEDAS, Jorge,SIME, Mairi,STEADMAN, Jon Graham Anthony,THEWLIS, Rachel Elizabeth Anne,TRANI, Giancarlo,WALTER, Daryl Simon
申请号：
ES10720006
公开号：
ES2590987T3
申请日:
2010.04.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: A is hydrogen, C1-4 alkyl, C1-3 alkoxy, C1-2 fluoroalkyl, halogen, NR6R7, Het, or phenyl, wherein the phenyl is optionally substituted with one, two or three substituents that are independently fluorine, chlorine, C1-3 alkyl or methoxy； wherein Het is: i) a six-membered heteroaromatic monocyclic ring containing one, two or three nitrogen atoms in the ring, or ii) a five-membered heteroaromatic monocyclic ring containing one, two or three heteroatoms that are independently N, O or S, in which at most one of the heteroatoms of the 5-member ring is O or S； and wherein Het is optionally substituted with one or two substituents that are independently C1-3 alkyl, fluorine, chlorine, OH (including a tautomer thereof), or methoxy； and wherein: R1 is hydrogen, chlorine, fluorine, bromine, C1 fluoroalkyl, cyano or C1-3 alkyl； R2 is hydrogen, fluorine, chlorine, bromine, C1 fluoroalkyl, cyano or C1-3 alkyl； R3 is hydrogen, fluorine or chlorine； R4 is hydrogen； R5 is hydrogen, fluorine, chlorine or methyl； and R6 and R7 are independently hydrogen or C1-3 alkyl； or R6 and R7 are taken together and are - (CH2) 2-O- (CH2) 2-, - (CH2) 2-O- (CH2) 3-, or - (CH2) n1- in which n1 is 3 , 4, 5 or 6； wherein, when A is hydrogen, C1-4 alkyl, C1-3 alkoxy, C1-2 fluoroalkyl, halogen or NR6R7, then R1 is chloro, fluorine, bromine, C1 fluoroalkyl, cyano or C1-3 alkyl, and at least one of R2 and R3 is different from hydrogen； and when A is optionally substituted Het or phenyl, then R1 is hydrogen, chlorine, fluorine, bromine, C1 fluoroalkyl, cyano or C1-3 alkyl, and at least one of R1, R2 and R3 is different from hydrogen； and wherein, when R5 is fluorine, chlorine or methyl, then R1 is chlorine, fluorine, C1 or methyl fluoroalkyl and R2 is hydrogen.Un compuesto de fórmula (I) o una de sus sales farmacéuticamente aceptables: en la que: A es hidrógeno, alquilo C1-4, alcoxi C1-3, fluoroalquilo C1-2, halógeno, NR6R7,
