SHUTTLEWORTH, Stephen Joseph,TOMASSI, Cyrille Davy,CECIL, Alexander Richard Liam,MACCORMICK, Somhairle,NODES, William John,SILVA, Franck Alexandre
申请号：
ES14725240
公开号：
ES2688815T3
申请日:
2014.05.12
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: each R / is independently selected from H and QR1； each Q is independently selected from a link, CO, CO2, NH, S, SO, SO2 or O； each R1 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl, C1-C10 alkyl-heteroaryl or C1-C10 heterocycloalkyl ； each L is independently selected from a 5-10 membered nitrogen-containing heteroaryl group； ** Formula ** W is the zinc -CONHOH binding group of structure: each R2 is independently hydrogen or C1 to C6 alkyl； and R3 is an aryl or heteroaryl； each aryl or heteroaryl may be substituted with up to three substituents selected from C1-C6 alkyl, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, amino, C1-C3 alkylamino, bis C1-C3 alkylamino, acylamino C1-C3, C1-C3 aminoalkyl, mono (C1-C3 alkyl) amino C1-C3 alkyl, bis (C1-C3 alkyl) amino C1-C3 alkyl, C1-C3 acylamino, C1-C3 alkyl sulfonylamino, halo, nitro, cyano, trifluoromethyl, carboxy, C1-C3 alkoxycarbonyl, aminocarbonyl, mono C1-C3 alkyl aminocarbonyl, bis C1-C3 alkylcarbonyl, -SO3H, C1-C3 alkylsulfonyl, aminosulfonyl, C1-C3 alkyl alkylsulfonyl and bis C1-C3 alkyl aminosulfon ； and each alkyl, alkenyl or alkynyl may be substituted with halogen, NH2, NO2 or hydroxyl.Un compuesto de la fórmula**Fórmula** o una sal farmacéuticamente aceptable del mismo, en donde: cada R/ se selecciona independientemente entre H y QR1； cada Q se selecciona independientemente entre un enlace, CO, CO2, NH, S, SO, SO2 u O； cada R1 se selecciona independientemente entre H, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, arilo, heteroarilo, cicloalquilo C1-C10, halógeno, alquilarilo C1-C10, alquil C1-C10-heteroarilo o heterocicloalquilo C1-C10； cada L se selecciona independientemente entre un grupo heteroarilo que contiene nitrógeno de 5 a 10 miembros；**Fórmula** W es el grupo de unión a cinc -CONHOH de estruct
