BLANK, Jutta,BORDAS, Vincent,COTESTA, Simona,GUAGNANO, Vito,RUEEGER, Heinrich,VAUPEL, Andrea
申请号：
ES14731799
公开号：
ES2651843T3
申请日:
2014.05.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of the formula (I), or a pharmaceutically acceptable salt thereof, ** Formula ** wherein ring C is selected from ** Formula ** i. and ii. ； A is selected from ** Formula ** B is selected from ** Formula ** R3 is selected from H, methyl, ethyl, - CH2F, - CF3, isopropyl, - OH, ethoxy, methoxy, cyclopropyl , - CH2OCH3 and - CH2OH； R4a is selected from H, (C1-C4) alkyl, (C3-C6) cycloalkyl, - (CH2) 2- OH, - (CH2) 2- O-CH3, - C (O) - NH (CH3) , - C (O) - N (CH3) 2, ** Formula ** R4b is selected from H, (C1-C4) alkyl, (C3-C6) cycloalkyl, - (CH2) 2- OH, - ( CH2) 2- O- CH3, - (CH2) 2- O- CH2- CF3, - (CH2) - CH (OH) - CF3 ,, - C (O) - NH (CH3), - C (O) - N (CH3) 2 ** Formula ** R5 is H； R1 is selected from H, methyl, chlorine and fluorine； R2 is selected from bromine, chlorine, fluorine, - O-CF3 and - CF3； R2a is fluorine； R8 is methyl； R15, R16, R18 and R21 are all methoxy； R17 is methyl or methoxy； R22, R23, R26, R27, R28, R30, R32 and R33 are all methyl； R24 is methyl or -CHF2； R25 is methyl or - NR9R10； R29 is H or methyl； R31 is H, methyl or methoxy； R34 is H or methyl； R9 is H or methyl； R10 is H, methyl or -C (O) - (C1-C3) alkyl； R35 is H, methyl, -C (O) CH3 or -C (O) OCH2CH3； and * indicates the point of attachment to the rest of the molecule； with the proviso that when ring C is i: ** Formula ** A is: ** Formula ** R1 is selected from methyl, chlorine and fluorine, B is: ** Formula ** R2 is chlorine, fluorine or - CF3, and the rest of the substituents are as defined herein, then R3 is selected from H, methyl, ethyl, - CH2F, - CF3, - OH, ethoxy, methoxy, - CH2OCH3 and - CH2OH.Un compuesto de la fórmula (I), o una sal farmacéuticamente aceptable del mismo,**Fórmula** en donde el anillo C se selecciona a partir de**Fórmula** i. y ii. ； A se selecciona a partir de**Fórmula** B se selecciona a partir de**Fórmula** R3 se selecciona a partir de H, metilo, etilo, - CH2F, - CF3, isopropilo, - OH, etoxilo, metoxilo, ciclopropilo, - CH2OCH3 y - CH2OH； R4a se seleccio
