LIN, CHU-CHUNG,LEE, KUANG-YUAN,LIU, YO-CHIN,LO, PIN,CHEN, RONG-JIUNN,LIU, CHEN-FU,CHEN, CHIH-MING,KING, CHI-HSIN RICHARD
申请号：
ES08874317
公开号：
ES2542880T3
申请日:
2008.11.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** in which each of R1 and R2, independently, is H, C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl； U is -O-, -NH-, -NH (CO) -, -NHSO-, or -NHSO2-； W is - (CH2) m-, -NH (CH2) n-, - (CH2) nNH-, -O (CH2) n-, - (CH2) nO-, -S (CH2) n-, - (CH2 ) nS-, -SO-, -SO (CH2) n-, - (CH2) nSO-, - SO2 (CH2) n-, or - (CH2) nSO2-, and m is 1, 2, or 3, and n is 0, 1, or 2； X is -O-； And it is ** Formula ** or ** Formula ** in which each of V and T, independently, is -CH- or -N-； R is H, halogen, nitro, cyano, amino, C 1-6 alkyl, C 1-6 alkoxy, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 1-10 heterocycloalkyl, aryl, or heteroaryl； and each of A1 and A2, independently, is C4-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted with halogen, nitro, cyano, amino, C1-6 alkyl, C1 alkoxy -6, C2-6 alkenyl, C2-6 alkynyl, aryl, or heteroaryl； or is optionally condensed with another C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl, each of which is optionally substituted with halogen, nitro, cyano, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl , C2-6 alkynyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl； and Z is -C (O), -OC (O) -, -NR'C (O) -, -OC (S) -, -NR'-C (S) -, or -OC (NH) -； wherein R 'is H, C1-6 alkyl, C3-10 cycloalkyl, C1-10 heterocycloalkyl, aryl, or heteroaryl.Un compuesto de fórmula (I):**Fórmula** en la que cada uno de R1 y R2, independientemente, es H, alquilo C1-6, cicloalquilo C3-10, heterocicloalquilo C1-10, arilo, o heteroarilo； U es -O-, -NH-, -NH(CO)-, -NHSO-, o -NHSO2-； W es -(CH2)m-, -NH(CH2)n-, -(CH2)nNH-, -O(CH2)n-, -(CH2)nO-, -S(CH2)n-, -(CH2)nS-, -SO-, -SO(CH2)n-, -(CH2)nSO-, - SO2(CH2)n-, o -(CH2)nSO2-, y m es 1, 2, o 3, y n es 0, 1, o 2； X is -O-； Y es**Fórmula** o **Fórmula** en las que cada uno de V y T, independientemente, es -CH- o -N-； R es H, halógeno, nitro, ciano, amino, alquilo C1-6, alcoxilo C1-6, alquenilo C2-6, alquin
