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2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines as 5-HT7 receptor antagonists
专利权人:
Sandra Ann Filla;Michael Philip Mazanetz;Valentina O. Badescu;Barry Peter Clark;John Mehnert;Sarah Lynne Hellman;Marta Maria Pineiro-Nunez;Michael Philip Cohen;Anne Marie Camp;Peter Thaddeus Gallagher
发明人:
Valentina O. Badescu,Anne Marie Camp,Barry Peter Clark,Michael Philip Cohen,Sandra Ann Filla,Peter Thaddeus Gallagher,Sarah Lynne Hellman,Michael Philip Mazanetz,Marta Maria Pineiro-Nunez,John Mehnert
申请号:
US12597255
公开号:
US08202873B2
申请日:
2008.05.07
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety:where A and B are each independently —C(H)═ or —N═, provided that at least one of A and B is —N═, n is 1-3, m is 0-3, and R1-4 are as defined herein.
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