TRAITEMENT DE L'INFLAMMATION EN UTILISANT DES CONJUGUÉS DE LLP2A-BISPHOSPHONATE ET DES CELLULES SOUCHES MÉSENCHYMATEUSES

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专利权人:

The Regents of the University of California

发明人:

申请号：

EP14850853.4

公开号：

EP3052104A4

申请日:

2014.10.03

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided.

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